SCHEMBL4424840

SCHEMBL4424840

Cn1ccnc1-c1nn(Cc2ccccc2)c2ccccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 4/20 0.56
F2RL3 Q96RI0 1/20 0.49
CNR1 P21554 1/20 0.49
ACHE P22303 1/20 0.49
CNR2 P34972 1/20 0.49
CYP1A2 P05177 4/20 0.48
CYP2D6 P10635 4/20 0.48
CYP3A4 P08684 2/20 0.48
KDM4E B2RXH2 2/20 0.48
HSD17B10 Q99714 2/20 0.48
NPC1 O15118 1/20 0.48
GMNN O75496 1/20 0.48
ALDH1A1 P00352 1/20 0.48
LMNA P02545 1/20 0.48
TP53 P04637 1/20 0.48
MAPT P10636 1/20 0.48
CYP2C9 P11712 1/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
NFKB1 P19838 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6011543 0.77 PDE5A (0.57) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL5564410 0.76 PDE5A (0.54) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL5558557 0.76 PDE5A (0.54) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL3621787 0.75 ALDH1A1 (0.67) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL13618343 0.75 F2RL3 (0.66) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL13777341 0.74 L3MBTL1 (0.62) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL5564174 0.73 PDE5A (0.54) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL9864880 0.73 CNR1 (0.55) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL5564260 0.72 PDE5A (1.00) PDE5AF2RL3CNR1ACHECNR2
SCHEMBL13865190 0.72 CYP2D6 (0.57) PDE5AF2RL3CNR1ACHECNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934311-B1 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER HEALTHCARE AG (DE) 2009-05-13 EP disclosed
EP-0934311-B1 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER HEALTHCARE AG (DE) 2009-05-13 EP disclosed
WO-2007065010-A2 ANTI-ANGIOGENESIS COMPOUNDS HIF BIO, INC. (US) 2007-06-07 WO disclosed
US-6462068-B1 CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 2002-10-08 US disclosed
US-6414009-B1 CARDIOVASCULAR DISORDERS; ANTICOAGULANTS BAYER AKTIENGESELLSCHAFT (DE) 2002-07-02 US disclosed
US-6410740-B1 CYCLIZATION OF THE CORRESPONDING AMIDE BAYER AKTIENGESELLSCHAFT (DE) 2002-06-25 US disclosed
US-6387940-B1 CARDIOVASCULAR DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 2002-05-14 US disclosed
US-6166027-A Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases BAYER AKTIENGESELLSCHAFT (DE) 2000-12-26 US disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed