Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A11 | P48066 | 4/20 | 0.42 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3689634 | 0.89 | SLC6A11 (0.41) | SLC6A11SLC6A1KIF11CYP2D6HTR2A | |
| SCHEMBL3694009 | 0.85 | SLC6A11 (0.39) | SLC6A11SLC6A1KIF11CYP2D6HTR2A | |
| SCHEMBL18349844 | 0.85 | CYP2D6 (0.42) | SLC6A11SLC6A1KIF11CYP2D6HTR2A | |
| SCHEMBL22380805 | 0.82 | SLC6A11 (0.44) | SLC6A11SLC6A1KIF11CYP2D6HTR2A | |
| SCHEMBL13575130 | 0.82 | PLA2G2A (0.44) | SLC6A11SLC6A1CYP2D6HTR2A | |
| SCHEMBL12004675 | 0.81 | PDE4B (0.51) | SLC6A11SLC6A1KIF11MEN1TP53 | |
| SCHEMBL12005099 | 0.81 | PDE4B (0.51) | SLC6A11SLC6A1KIF11MEN1TP53 | |
| SCHEMBL12004703 | 0.81 | PDE4B (0.51) | SLC6A11SLC6A1KIF11MEN1TP53 | |
| SCHEMBL3690892 | 0.81 | HDAC6 (0.38) | SLC6A11SLC6A1CYP2D6HTR2A | |
| SCHEMBL31677916 | 0.81 | L3MBTL1 (0.36) | SLC6A11SLC6A1KIF11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081949-A2 | TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | Dharmacon, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-2064223-A2 | DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | Dharmacon, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008036825-A2 | DUPLEX OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036841-A2 | TRIPARTITE OLIGONUCLEOTIDE COMPLEXES AND METHODS FOR GENE SILENCING BY RNA INTERFERENCE | DHARMACON, INC. (US) | 2008-03-27 | — | — | WO | disclosed |