⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668609 | 0.73 | HPGD (0.31) | — | |
| SCHEMBL16661274 | 0.69 | KDM4E (0.45) | — | |
| SCHEMBL31138696 | 0.69 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL11623789 | 0.69 | HPGD (0.43) | — | |
| SCHEMBL31138639 | 0.68 | — | — | |
| SCHEMBL25791857 | 0.68 | NT5E (0.32) | — | |
| SCHEMBL27174299 | 0.67 | ALOX5AP (0.43) | — | |
| SCHEMBL31138525 | 0.67 | ULK1 (0.32) | — | |
| SCHEMBL25281827 | 0.67 | KDM4E (0.37) | — | |
| SCHEMBL31254670 | 0.67 | NOTUM (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635703-B2 | Imidazole substituted pyrazole kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-22 | — | — | US | disclosed |
| US-7635703-B2 | Imidazole substituted pyrazole kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-22 | — | — | US | disclosed |
| US-7635703-B2 | Imidazole substituted pyrazole kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-22 | — | — | US | disclosed |
| US-20080103172-A1 | IMIDAZOLE SUBSTITUTED PYRAZOLE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-01 | — | — | US | disclosed |
| US-20080103172-A1 | IMIDAZOLE SUBSTITUTED PYRAZOLE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-01 | — | — | US | disclosed |
| US-20080103172-A1 | IMIDAZOLE SUBSTITUTED PYRAZOLE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-01 | — | — | US | disclosed |
| WO-2008048503-A2 | IMIDAZOLE SUBSTITURED PYRAZOLE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-24 | — | — | WO | disclosed |