Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.54 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.54 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | DNPH1 | O43598 | 2/20 | 0.54 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.54 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41365 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL780585 | 0.90 | ADORA3 (0.66) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL4581742 | 0.88 | P2RY1 (0.70) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL12541780 | 0.85 | DOT1L (0.54) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL28672421 | 0.84 | P2RY1 (0.57) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL21839786 | 0.84 | RNASEL (0.66) | ADORA1P2RY1P2RY2SMN1; SMN2SRC | |
| SCHEMBL900708 | 0.83 | ADORA1 (0.70) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL28687027 | 0.83 | P2RY1 (0.56) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL8768536 | 0.83 | DNPH1 (0.54) | ADORA3ADORA1P2RY1P2RY2SMN1; SMN2 | |
| SCHEMBL11647168 | 0.82 | P2RY1 (0.68) | ADORA1P2RY1P2RY2SMN1; SMN2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024019801-A1 | SYSTEMS AND METHODS FOR PROMOTING TRANS-SPLICING | TACIT THERAPEUTICS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |
| EP-4125930-A1 | DUAL-ACTING SIRNA BASED MODULATION OF C9ORF72 | University Of Massachusetts (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021195510-A1 | DUAL-ACTING SIRNA BASED MODULATION OF C9ORF72 | UNIVERSITY OF MASSACHUSETTS (US) | 2021-09-30 | — | — | WO | disclosed |
| EP-2046993-A2 | RNA SILENCING COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUNTINGTON'S DISEASE | University of Massachusetts (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008005562-A2 | RNA SILENCING COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUNTINGTON'S DISEASE | UNIVERSITY OF MASSACHUSETTS (US) | 2008-01-10 | — | — | WO | disclosed |