Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.55 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4424444 | 0.88 | KMT2A (0.78) | KMT2AHSD17B10ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4423531 | 0.79 | ALDH1A1 (0.72) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL4423549 | 0.79 | ALDH1A1 (0.83) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL22767345 | 0.78 | LMNA (0.74) | KMT2AALDH1A1MEN1SMN1; SMN2HPGD | |
| SCHEMBL4421403 | 0.78 | LMNA (0.91) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL22767393 | 0.77 | SMN1; SMN2 (0.72) | KMT2AALDH1A1MEN1SMN1; SMN2HPGD | |
| SCHEMBL4423010 | 0.77 | SLC6A5 (0.74) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4423014 | 0.76 | LMNA (1.00) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL4426219 | 0.76 | ALDH1A1 (0.64) | KMT2AHSD17B10ALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4423374 | 0.75 | ALDH1A1 (0.66) | KMT2AALDH1A1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1703909-B1 | 1-BENZOYL-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | claimed |
| EP-1703909-B1 | 1-BENZOYL-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | EP | disclosed |