Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HAT1 | O14929 | 11/20 | 0.48 |
| ▸ | EP300 | Q09472 | 11/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420768 | 0.88 | HDAC1 (0.47) | MEN1KMT2ANPC1RAB9AHAT1 | |
| SCHEMBL4413853 | 0.77 | CREBBP (0.49) | KMT2AEP300HDAC1HDAC2 | |
| SCHEMBL3173586 | 0.77 | MEN1 (0.49) | MEN1KMT2ANPC1RAB9AHAT1 | |
| SCHEMBL20267057 | 0.76 | HDAC1 (0.62) | MEN1KMT2ANPC1RAB9AHDAC1 | |
| SCHEMBL4414234 | 0.76 | KMT2A (0.51) | KMT2AHDAC1HDAC2 | |
| SCHEMBL4272168 | 0.73 | EPHX2 (0.37) | — | |
| SCHEMBL4415025 | 0.72 | KMT2A (0.39) | KMT2AHDAC1HDAC3 | |
| SCHEMBL7960871 | 0.72 | HDAC1 (0.60) | MEN1KMT2ANPC1RAB9AHDAC1 | |
| SCHEMBL10288963 | 0.71 | HDAC1 (0.62) | MEN1KMT2ANPC1HDAC1HDAC2 | |
| SCHEMBL23162787 | 0.70 | ADAM17 (0.59) | NPC1RAB9AHDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |