Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414234 | 0.89 | KMT2A (0.51) | KMT2AALDH1A1F10MAPTLMNA | |
| SCHEMBL3164868 | 0.79 | PTGDR2 (0.40) | KMT2AALDH1A1ROCK1EPHX2MAPT | |
| SCHEMBL4413853 | 0.79 | CREBBP (0.49) | KMT2AALDH1A1F10EPHX2MAPT | |
| SCHEMBL4420768 | 0.77 | HDAC1 (0.47) | KMT2AEPHX2HDAC3HDAC1 | |
| SCHEMBL4424045 | 0.75 | MCL1 (0.48) | KMT2AALDH1A1KDM4E | |
| SCHEMBL4426339 | 0.72 | MEN1 (0.49) | KMT2AHDAC3HDAC1 | |
| SCHEMBL3165167 | 0.72 | PTGDR2 (0.44) | KMT2AALDH1A1EPHX2MAPTLMNA | |
| SCHEMBL4272168 | 0.71 | EPHX2 (0.37) | EPHX2PPARGPPARA | |
| SCHEMBL12678728 | 0.69 | POLB (0.45) | ALDH1A1EPHX2MAPTLMNAKDM4E | |
| SCHEMBL4425054 | 0.67 | GPR52 (0.36) | EPHX2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |