Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 7/20 | 0.49 |
| ▸ | TNFSF11 | O14788 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414234 | 0.86 | KMT2A (0.51) | CREBBPKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL4421324 | 0.80 | OXER1 (0.41) | KDM4EALDH1A1KMT2AEP300HDAC1 | |
| SCHEMBL4415025 | 0.79 | KMT2A (0.39) | KDM4EALDH1A1KMT2AEPHX2LMNA | |
| SCHEMBL4426339 | 0.77 | MEN1 (0.49) | KMT2AEP300HDAC1HDAC2 | |
| SCHEMBL3175180 | 0.77 | CREBBP (0.46) | CREBBPKDM4EALDH1A1THRBKMT2A | |
| SCHEMBL4420768 | 0.73 | HDAC1 (0.47) | KMT2AEPHX2EP300HDAC1HDAC2 | |
| SCHEMBL4272168 | 0.70 | EPHX2 (0.37) | EPHX2 | |
| SCHEMBL4424045 | 0.69 | MCL1 (0.48) | KDM4EALDH1A1KMT2A | |
| SCHEMBL4425054 | 0.68 | GPR52 (0.36) | EPHX2LMNAMAPT | |
| SCHEMBL28620498 | 0.67 | CREBBP (1.00) | CREBBPKDM4EALDH1A1EP300LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |