Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997559 | 0.97 | BRD4 (0.42) | BRD4BRD2LMNACHRM2CHRM4 | |
| SCHEMBL10525669 | 0.95 | BRD4 (0.39) | BRD4BRD2LMNACHRM2CHRM4 | |
| SCHEMBL1440029 | 0.92 | ALDH1A1 (0.37) | BRD4BRD2LMNACHRM2CHRM4 | |
| SCHEMBL2927812 | 0.90 | CHRM2 (0.33) | BRD4BRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL2929497 | 0.87 | CHRM2 (0.32) | BRD4BRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL15168977 | 0.85 | BRD4 (0.41) | BRD4BRD2LMNACHRM2CHRM4 | |
| SCHEMBL20919753 | 0.84 | CHRM2 (0.33) | BRD4BRD2CHRM2CHRM4CHRM5 | |
| SCHEMBL420538 | 0.84 | — | — | |
| SCHEMBL2363506 | 0.83 | BRD4 (0.48) | BRD4BRD2LMNACHRM2CHRM4 | |
| SCHEMBL600282 | 0.83 | BRD4 (0.52) | BRD4BRD2LMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394955-B2 | 2,4 (4,6) pyrimidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | claimed |
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | FREYNE EDDY JEAN EDGARD (BE) | 2012-03-15 | — | — | US | claimed |
| EP-2342173-A1 | SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS | Novartis AG (CH) | 2011-07-13 | — | — | EP | claimed |
| US-20100160310-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-06-24 | — | — | US | claimed |
| WO-2010043584-A1 | SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS | NOVARTIS AG (CH) | 2010-04-22 | — | — | WO | claimed |
| EP-1448198-B1 | NICOTIN-OR ISONICOTIN BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-10-31 | — | — | EP | claimed |
| EP-1824856-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-29 | — | — | EP | claimed |
| WO-2006061415-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-15 | — | — | WO | claimed |
| WO-2024052871-A1 | NOVEL RUTHENIUM COMPLEXES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS USED IN THIS METHOD, METHOD OF THEIR SYNTHESIS AND USE OF NOVEL RUTHENIUM COMPLEXES IN OLEFIN METATHESIS REACTIONS | UNIWERSYTET WARSZAWSKI (PL) | 2024-03-14 | — | — | WO | disclosed |
| CN-116234800-A | Copper complexes for the treatment of neurodegenerative disorders | ALS治疗发展学会 | 2023-06-06 | — | — | CN | disclosed |
| CN-114555565-A | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-109476628-B | Sulfonylcycloalkylamide compounds as TRPA1 modulators | 豪夫迈·罗氏有限公司 | 2022-01-11 | — | — | CN | disclosed |
| WO-2018134800-A1 | DIALKYL COMPLEXES OF GALLIUM AND INDIUM AND THEIR USE FOR PREPARATION OF POLYLACTIDE-PHARMACEUTICALLY ACTIVE COMPOUND CONJUGATES AND FOR IMMORTAL RING-OPENING POLYMERIZATION OF HETEROC CLIC MONOMERS | UNIWERSYTET WARSZAWSKI (PL) | 2018-07-26 | — | — | WO | disclosed |
| CN-107099257-A | Adhesive sheet, display, and method for producing same | 琳得科株式会社 | 2017-08-29 | — | — | CN | disclosed |
| US-6620811-B2 | Adenosine receptor antagonists; nervous system and cardiovascular disorders; Parkinson*s, Huntington*s, and Alzheimer* disease; antiasthmatics, antiallergens | HOFFMANN-LA ROCHE INC. | 2003-09-16 | — | — | US | disclosed |
| US-20030134854-A1 | Isonicotin- and nicotinamide derivatives of benzothiazoles | F.HOFFMANN-LA ROCHE AG (CH) | 2003-07-17 | — | — | US | disclosed |
| WO-2003043636-A1 | NICOTIN-OR ISONICOTIN BENZOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-30 | — | — | WO | disclosed |
| CN-1383025-A | Electrically controlled variable-wavelength filter and its prepearing process | UNIV SHANGHAI JIAOTONG (CN) | 2002-12-04 | — | — | CN | disclosed |
| US-6281352-B1 | ANTIINFLAMMATORY AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-08-28 | — | — | US | disclosed |
| US-4892959-A | REACTING N-METHYLPYRROLIDONE WITH HYDROGEN OVER A COPPER CHROMITE CATALYST | TEXACO CHEMICAL CO. (US) | 1990-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134854-A1 | Isonicotin- and nicotinamide derivatives of benzothiazoles | ADORA1, ADORA2A, ADORA3 | BRD4 988/4885BRD2 1051/4885LMNA 2622/4885 |
| US-20120065395-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | NR0B1, NR1H3, NCOA3 | BRD4 1014/4885BRD2 1699/4885LMNA 2533/4885 |
| US-20100160310-A1 | 2,4 (4,6) PYRIMIDINE DERIVATIVES | NR1H3, NR1H2, NR0B1 | BRD4 1055/4885BRD2 1765/4885LMNA 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.