Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 5/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4684865 | 0.86 | HIF1A (0.57) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3673327 | 0.84 | HIF1A (0.59) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4684868 | 0.84 | HIF1A (0.59) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7995934 | 0.83 | HIF1A (0.57) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7995945 | 0.83 | HIF1A (0.57) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7151741 | 0.81 | HIF1A (0.55) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3049101 | 0.77 | ALDH1A1 (0.50) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL682779 | 0.77 | ALDH1A1 (0.52) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3666480 | 0.76 | AKR1C3 (0.63) | HIF1ALMNAAKR1C3AKR1C2TSHR | |
| SCHEMBL20459369 | 0.76 | PDE4A (0.60) | HIF1APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1679967-A4 | METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUS FOR TREATMENT, MODIFICATION AND MANAGEMENT OF PAIN | CELGENE CORP (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1755589-A4 | METHODS OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR THE TREATMENT AND MANAGEMENT OF PULMONARY HYPERTENSION | CELGENE CORP (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1755589-A1 | METHODS OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR THE TREATMENT AND MANAGEMENT OF PULMONARY HYPERTENSION | CELGENE CORPORATION (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1684756-A1 | CYTOKINE INHIBITORY DRUGS FOR TREATMENT OF MACULAR DEGENERATION | CELGENE CORPORATION (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-1679967-A2 | METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUS FOR TREATMENT, MODIFICATION AND MANAGEMENT OF PAIN | CELGENE CORPORATION (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005102317-A1 | METHODS OF USING AND COMPOSITIONS COMPRISING PDE4 MODULATORS FOR THE TREATMENT AND MANAGEMENT OF PULMONARY HYPERTENSION | CELGENE CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |
| WO-2005043971-A2 | METHODS OF USING AND COMPOSITIONS COMPRISING SELECTIVE CYTOKINE INHIBITORY DRUGS FOR TREATMENT, MODIFICATION AND MANAGEMENT OF PAIN | CELGENE CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005044269-A1 | CYTOKINE INHIBITORY DRUGS FOR TREATMENT OF MACULAR DEGENERATION | CELGENE CORPORATION (US) | 2005-05-19 | — | — | WO | disclosed |