Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CDC42 | P60953 | 1/20 | 0.50 |
| ▸ | RAC1 | P63000 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673327 | 0.98 | HIF1A (0.59) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL7995945 | 0.97 | HIF1A (0.57) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL3666480 | 0.91 | AKR1C3 (0.63) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL4684868 | 0.87 | HIF1A (0.59) | HIF1AAKR1C3AKR1C2PDE4APDE4B | |
| SCHEMBL14032691 | 0.86 | ACHE (0.61) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL5122373 | 0.86 | ACHE (0.61) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL490776 | 0.86 | ACHE (0.61) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL4684865 | 0.85 | HIF1A (0.57) | HIF1AAKR1C3AKR1C2PDE4APDE4B | |
| Hydrochloric Acid SCHEMBL3225395 | 0.84 | ACHE (0.59) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL4426909 | 0.83 | HIF1A (0.58) | HIF1AAKR1C3AKR1C2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |