Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.55 |
| ▸ | PDE4A | P27815 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CDC42 | P60953 | 1/20 | 0.51 |
| ▸ | RAC1 | P63000 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995945 | 0.98 | HIF1A (0.57) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL7995934 | 0.98 | HIF1A (0.57) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL3666480 | 0.92 | AKR1C3 (0.63) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL4684868 | 0.88 | HIF1A (0.59) | HIF1AAKR1C3AKR1C2PDE4APDE4B | |
| SCHEMBL14032691 | 0.87 | ACHE (0.61) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL5122373 | 0.87 | ACHE (0.61) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL490776 | 0.87 | ACHE (0.61) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL4684865 | 0.87 | HIF1A (0.57) | HIF1AAKR1C3AKR1C2PDE4APDE4B | |
| Hydrochloric Acid SCHEMBL3225395 | 0.85 | ACHE (0.59) | HIF1AAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL4426909 | 0.84 | HIF1A (0.58) | HIF1AAKR1C3AKR1C2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | BIEDIGER RONALD J | 2006-12-07 | — | — | US | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | VCAM1, ICAM1, ITGA1 | HIF1A 216/4885AKR1C3 809/4885AKR1C2 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.