Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12433264 | 1.00 | CTSK (0.51) | CTSKCTSSMEN1KMT2AMAPT | |
| SCHEMBL9738069 | 0.88 | FOLH1 (0.60) | MMP1MMP3MMP9FOLH1ACE | |
| SCHEMBL9738061 | 0.88 | FOLH1 (0.60) | MMP1MMP3MMP9FOLH1ACE | |
| SCHEMBL23008180 | 0.86 | CTSK (0.52) | CTSKCTSSMEN1KMT2AMAPT | |
| SCHEMBL19068560 | 0.86 | CTSK (0.52) | CTSKCTSSMEN1KMT2AMAPT | |
| SCHEMBL901542 | 0.84 | MME (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL15101628 | 0.84 | MME (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL901541 | 0.84 | MME (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12511241 | 0.84 | CTSK (0.48) | CTSKCTSSMEN1KMT2AMAPT | |
| SCHEMBL15384071 | 0.84 | CTSK (0.48) | CTSKCTSSMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-B1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX SA (FR) | 2009-03-04 | — | — | EP | disclosed |
| US-7217733-B2 | ACE inhibitor derivatives | NICOX, S.A. (FR) | 2007-05-15 | — | — | US | disclosed |
| EP-0176903-A1 | Thiomorpholines | MERCK PATENT GmbH (DE) | 1986-04-09 | — | — | EP | disclosed |