Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425073 | 0.76 | NOTUM (0.50) | NOTUMKCNH2IDH1 | |
| SCHEMBL19402304 | 0.76 | NOTUM (0.47) | NOTUMKCNH2IDH1 | |
| SCHEMBL10900906 | 0.68 | ALDH1A1 (0.51) | NOTUMKCNH2 | |
| SCHEMBL16046407 | 0.65 | IDH1 (0.44) | NOTUMKCNH2IDH1 | |
| SCHEMBL30946872 | 0.65 | DYRK1A (0.40) | — | |
| SCHEMBL27285378 | 0.65 | DYRK1A (0.40) | — | |
| SCHEMBL16043774 | 0.65 | IDH1 (0.44) | NOTUMKCNH2IDH1 | |
| SCHEMBL3426673 | 0.65 | NOTUM (0.52) | NOTUM | |
| SCHEMBL27906474 | 0.65 | NOTUM (0.49) | NOTUM | |
| SCHEMBL27284757 | 0.65 | LMNA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-B1 | IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | disclosed |