Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | ACP3 | P15309 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627469 | 0.84 | ALDH1A1 (0.54) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL7271927 | 0.81 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2TSHRLMNAHTT | |
| SCHEMBL11707796 | 0.80 | TSHR (0.57) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL12395373 | 0.80 | ALDH1A1 (0.56) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL49507 | 0.78 | ALDH1A1 (0.54) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL3384133 | 0.77 | TSHR (0.57) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL11802999 | 0.77 | TSHR (0.57) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL3642758 | 0.77 | TSHR (0.61) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL7126589 | 0.76 | ALDH1A1 (0.56) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA | |
| SCHEMBL5035510 | 0.76 | ACP3 (0.55) | ALDH1A1ACP3SMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114940-A1 | AZA-ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 613 | AstraZeneca AB (SE) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008100715-A1 | AZA-ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS - 613 | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |