Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126589 | 0.85 | ALDH1A1 (0.56) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL5035510 | 0.85 | ACP3 (0.55) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL4428033 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| Water SCHEMBL6057603 | 0.84 | ACP3 (0.54) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL27780284 | 0.83 | ALDH1A1 (0.52) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL27462574 | 0.83 | ACP3 (0.52) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL12395373 | 0.82 | ALDH1A1 (0.56) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL10531013 | 0.81 | LMNA (0.54) | ALDH1A1TSHRSMN1; SMN2LMNAHTT | |
| SCHEMBL923837 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 | |
| SCHEMBL49507 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRSMN1; SMN2LMNAACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432706-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | Bayer Pharmaceuticals Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027085-A2 | 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |