Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23098378 | 0.82 | ADK (0.56) | LMNAMTORHBBPMP22ADK | |
| SCHEMBL15855041 | 0.81 | NT5E (0.40) | NT5EADK | |
| SCHEMBL16629487 | 0.80 | LMNA (0.50) | LMNAMTORBLMGMNNALDH1A1 | |
| SCHEMBL21275623 | 0.80 | LMNA (0.50) | LMNAMTORBLMGMNNALDH1A1 | |
| SCHEMBL5888717 | 0.79 | ALDH1A1 (0.38) | LMNAMTORNT5EALDH1A1HTT | |
| SCHEMBL41572 | 0.79 | LMNA (0.62) | LMNAMTORBLMGMNNALDH1A1 | |
| SCHEMBL2579580 | 0.79 | LMNA (0.62) | LMNAMTORBLMGMNNALDH1A1 | |
| SCHEMBL5888462 | 0.79 | LMNA (0.49) | LMNAMTORBLMGMNNALDH1A1 | |
| SCHEMBL14441083 | 0.79 | LMNA (0.62) | LMNAMTORBLMGMNNALDH1A1 | |
| SCHEMBL18512948 | 0.79 | LMNA (0.62) | LMNAMTORBLMGMNNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804821-A4 | HCV NS3-NS4A PROTEASE INHIBITION | VERTEX PHARMA (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1804821-A2 | HCV NS3-NS4A PROTEASE INHIBITION | Vertex Pharmaceuticals, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006039488-A2 | HCV NS3-NS4A PROTEASE INHIBITION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-04-13 | — | — | WO | disclosed |