Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423633 | 0.82 | MAPK14 (0.51) | MAPK14RAF1RAB9AHPGDMAPT | |
| SCHEMBL4420926 | 0.80 | MAPK14 (0.56) | MAPK14RAF1HPGDMAPTLMNA | |
| SCHEMBL3245493 | 0.70 | RAF1 (0.83) | MAPK14RAF1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL5596997 | 0.67 | MAPT (0.43) | RAB9AHPGDMAPTLMNA | |
| SCHEMBL9191547 | 0.65 | ALDH1A1 (0.46) | MAPK14RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL3220088 | 0.65 | MAPK14 (0.55) | MAPK14RAF1HPGDMAPTUSP2 | |
| SCHEMBL6313081 | 0.65 | LMNA (0.39) | MAPK14RAB9ASMN1; SMN2MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL9261683 | 0.64 | ALDH1A1 (0.45) | MAPK14RAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL13388156 | 0.62 | EPAS1 (0.39) | RAB9AHPGDSMN1; SMN2MAPT | |
| SCHEMBL13315128 | 0.62 | MAPK14 (0.49) | MAPK14RAF1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4344960-B2 | — | — | 2009-10-14 | — | — | JP | claimed |
| JP-2001526687-A | — | — | 2001-12-18 | — | — | JP | claimed |
| EP-1019040-A4 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER AG (US) | 2000-10-04 | — | — | EP | claimed |
| EP-1019040-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | Bayer Corporation (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1998052558-A1 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS | BAYER CORPORATION (US) | 1998-11-26 | — | — | WO | claimed |