Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 4/20 | 0.39 |
| ▸ | KDM4A | O75164 | 4/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432530 | 0.85 | KDM4E (0.47) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4433052 | 0.84 | DAO (0.49) | KDM4EALDH1A1KDM4AKDM5BPDE3B | |
| SCHEMBL4431808 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1MMP1MMP2MMP9 | |
| SCHEMBL4433888 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1KDM6BKDM4AKDM4D | |
| SCHEMBL3912930 | 0.81 | KDM4E (0.53) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4432204 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1KDM6BKDM4AKDM4D | |
| SCHEMBL11836870 | 0.80 | BRS3 (0.49) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL4431911 | 0.80 | AR (0.44) | KDM4EALDH1A1GAA | |
| SCHEMBL4428237 | 0.78 | KDM4E (0.50) | KDM4EKDM6BKDM4AKDM4DHIF1AN | |
| SCHEMBL4430819 | 0.77 | BRS3 (0.46) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |