Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | BRS3 | P32247 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432530 | 0.84 | KDM4E (0.47) | DAOKDM4EKDM4AKDM4CKDM5B | |
| SCHEMBL4428820 | 0.84 | KDM4E (0.47) | KDM4EKDM4AKDM5BPDE3BPDE3A | |
| SCHEMBL4433888 | 0.81 | KDM4E (0.53) | BRS3KDM4EKDM4AKDM5BALDH1A1 | |
| SCHEMBL3912930 | 0.80 | KDM4E (0.53) | DAOBRS3KDM4EKDM4AKDM4C | |
| SCHEMBL4432204 | 0.79 | KDM4E (0.43) | BRS3KDM4EKDM4AKDM5BALDH1A1 | |
| SCHEMBL11836870 | 0.79 | BRS3 (0.49) | BRS3KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4431911 | 0.79 | AR (0.44) | DAOKDM4EALDH1A1ARMEN1 | |
| SCHEMBL4428237 | 0.77 | KDM4E (0.50) | DAOBRS3KDM4EKDM4AKDM4C | |
| SCHEMBL4430819 | 0.76 | BRS3 (0.46) | BRS3KDM4E | |
| SCHEMBL4438825 | 0.76 | BRS3 (0.42) | BRS3KDM4ELMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |