Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 6/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.54 |
| ▸ | GCGR | P47871 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082102 | 1.00 | TEK (0.60) | TEKGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL27881874 | 0.93 | LMNA (0.59) | TEKKDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL21614233 | 0.83 | ALDH1A1 (0.55) | TEKGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL4426390 | 0.82 | RAF1 (0.57) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7228732 | 0.82 | RAF1 (0.57) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL822678 | 0.81 | PTGER1 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL27934228 | 0.81 | TEK (0.49) | TEKGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL5079652 | 0.81 | MAPK14 (0.59) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4422522 | 0.81 | MAPK14 (0.59) | TEKMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5078877 | 0.81 | MAPK14 (0.53) | TEKMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487436-A4 | COMBINATION THERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS | SIGNAL PHARM INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1487436-A1 | COMBINATION THERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS | Signal Pharmaceuticals, Inc. (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003075917-A1 | COMBINATION THERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| EP-0623126-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014081-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-07-22 | — | — | WO | disclosed |