Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 17/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440181 | 0.80 | NNMT (0.33) | — | |
| SCHEMBL7011434 | 0.77 | TXNRD1 (0.48) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL2516681 | 0.76 | TXNRD1 (0.42) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL2516684 | 0.76 | TXNRD1 (0.42) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL2516685 | 0.76 | TXNRD1 (0.42) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL5021634 | 0.74 | TXNRD1 (0.46) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL16648934 | 0.73 | TXNRD1 (0.53) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL14048719 | 0.73 | TXNRD1 (0.47) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL13767339 | 0.72 | TXNRD1 (0.44) | TXNRD1S1PR4MAPTS1PR1MAPK1 | |
| SCHEMBL21617705 | 0.72 | TXNRD1 (0.51) | TXNRD1S1PR4MAPTS1PR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137195-A1 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008128953-A1 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |