Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428147 | 0.95 | CTSL (0.40) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4429535 | 0.92 | CTSL (0.41) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4429532 | 0.85 | CTSL (0.43) | CTSLCTSSCTSKCTSBMAPK14 | |
| SCHEMBL4432030 | 0.83 | CTSL (0.34) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4438784 | 0.82 | CTSL (0.34) | CTSLCTSSCTSB | |
| SCHEMBL4429647 | 0.81 | CTSS (0.38) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4428152 | 0.81 | CTSL (0.40) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4432656 | 0.80 | CTSS (0.40) | CTSLCTSSCTSKCTSB | |
| SCHEMBL3317671 | 0.80 | CTSL (0.50) | CTSLCTSSCTSKCTSBMAPK14 | |
| SCHEMBL3318986 | 0.79 | CTSL (0.52) | CTSLCTSSCTSKCTSBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118106-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | claimed |
| WO-2008107368-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | claimed |
| EP-2118106-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited (GB) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008107368-A1 | PURINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-09-12 | — | — | WO | disclosed |