Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 18/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31409453 | 1.00 | ADORA1 (0.62) | ADORA1ALDH1A1PKMSMN1; SMN2ADORA3 | |
| SCHEMBL31370980 | 0.90 | ALDH1A1 (0.59) | ADORA1ALDH1A1PKMSMN1; SMN2ADORA3 | |
| SCHEMBL13929510 | 0.90 | ALDH1A1 (0.61) | ADORA1ALDH1A1PKMSMN1; SMN2ADORA3 | |
| SCHEMBL26012324 | 0.88 | ALDH1A1 (0.57) | ADORA1ALDH1A1PKMSMN1; SMN2ADORA3 | |
| SCHEMBL26013193 | 0.88 | ADORA1 (0.58) | ADORA1ALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL4428648 | 0.86 | ADORA1 (0.85) | ADORA1ALDH1A1PKMSMN1; SMN2SLC6A3 | |
| SCHEMBL26014395 | 0.86 | ADORA1 (0.55) | ADORA1ALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL26010525 | 0.85 | KDM4E (0.64) | ADORA1ALDH1A1SMN1; SMN2ADORA3ADORA2A | |
| SCHEMBL13929771 | 0.84 | ADORA1 (0.62) | ADORA1ALDH1A1PKMSMN1; SMN2SLC6A3 | |
| SCHEMBL4427010 | 0.84 | ADORA1 (0.74) | ADORA1ALDH1A1ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1455785-B1 | SUBSTITUTED 2-THIO-3,5-DICYANO-4-PHENYL-6-AMINOPYRIDINES AND THE USE OF THE SAME | BAYER HEALTHCARE AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007073855-A1 | USE OF ADENOSINE A1 RECEPTOR AGONISTS FOR THE PROTECTION OF RENAL CELLS AGAINST TOXIC EFFECTS CAUSED BY AMINOGLYCOSIDES DURING TREATMENT OF INFECTIOUS DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-05 | — | — | WO | disclosed |
| US-20060217373-A1 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same | BAYER HEALTHCARE AG (DE) | 2006-09-28 | — | — | US | disclosed |
| US-7109218-B2 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same | BAYER HEALTHCARE AG (DE) | 2006-09-19 | — | — | US | disclosed |
| US-20050227972-A1 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same | BAYER HEALTHCARE AG (DE) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227972-A1 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same | TPMT, QDPR, TUBB6 | ADORA1 998/4885ALDH1A1 686/4885PKM 740/4885 |
| US-20060217373-A1 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same | TPMT, QDPR, TUBB6 | ADORA1 998/4885ALDH1A1 686/4885PKM 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.