Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.61 |
| ▸ | CTSL | P07711 | 3/20 | 0.61 |
| ▸ | CTSB | P07858 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927885 | 0.99 | CTSK (0.60) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL4107743 | 0.97 | CTSK (0.58) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL16612115 | 0.89 | KMT2A (0.58) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL7279646 | 0.85 | KMT2A (0.54) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL9354941 | 0.82 | ALDH1A1 (0.53) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL14030742 | 0.82 | KMT2A (0.54) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL4104897 | 0.82 | CTSK (0.44) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL4425947 | 0.81 | CTSK (0.43) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL9358225 | 0.81 | KMT2A (0.50) | CTSKCTSLCTSBMEN1KMT2A | |
| SCHEMBL9358292 | 0.79 | ALDH1A1 (0.53) | CTSKCTSLCTSBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858509-A4 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1858509-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094003-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |