Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.43 |
| ▸ | CTSB | P07858 | 4/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429871 | 0.81 | CTSK (0.61) | CTSKCTSLCTSBALDH1A1L3MBTL1 | |
| SCHEMBL3927885 | 0.80 | CTSK (0.60) | CTSKCTSLCTSBALDH1A1L3MBTL1 | |
| SCHEMBL4107743 | 0.79 | CTSK (0.58) | CTSKCTSLCTSBALDH1A1L3MBTL1 | |
| SCHEMBL16825111 | 0.78 | ALDH1A1 (0.57) | FNTAFNTBPGGT1BALDH1A1L3MBTL1 | |
| SCHEMBL4121338 | 0.76 | CTSK (0.47) | CTSKCTSLCTSBALDH1A1MEN1 | |
| SCHEMBL3915522 | 0.76 | CTSK (0.44) | CTSKCTSLCTSBALDH1A1L3MBTL1 | |
| SCHEMBL28123156 | 0.74 | ENPP2 (0.54) | FNTAFNTBPGGT1BALDH1A1F13A1 | |
| SCHEMBL4104897 | 0.72 | CTSK (0.44) | CTSKCTSLCTSBL3MBTL1MEN1 | |
| SCHEMBL4112483 | 0.72 | CTSK (0.45) | CTSKCTSLCTSBALDH1A1CASP3 | |
| SCHEMBL14529138 | 0.71 | ENPP2 (0.53) | ALDH1A1L3MBTL1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858509-A4 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1858509-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094003-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |