Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599761 | 0.84 | SIRT6 (0.57) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| SCHEMBL6436102 | 0.84 | KDM4E (0.54) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| SCHEMBL4427577 | 0.84 | MAPT (0.54) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| SCHEMBL2174830 | 0.82 | PRKDC (0.62) | ALDH1A1NPC1RAB9ALMNAKDM4E | |
| SCHEMBL1599675 | 0.79 | SIRT6 (0.51) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4438793 | 0.78 | MAPT (0.55) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| SCHEMBL6473253 | 0.77 | ALDH1A1 (0.65) | SIRT6ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11262976 | 0.77 | PIK3CD (0.68) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL25231967 | 0.76 | PIK3CD (0.66) | SIRT6ALDH1A1HTR3ANPC1RAB9A | |
| SCHEMBL29567678 | 0.74 | SIRT6 (0.56) | SIRT6ALDH1A1HTR3ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125822-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008074788-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-06-26 | — | — | WO | disclosed |