Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.54 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL430257 | 0.85 | ALOX5 (0.51) | NR1H4ALOX5MAOBALDH1A1CYP3A4 | |
| Acetonitrile SCHEMBL29178537 | 0.75 | TYR (0.83) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| SCHEMBL545307 | 0.74 | MTNR1A (0.49) | NR1H4ALOX5MAOBALDH1A1CYP3A4 | |
| SCHEMBL133876 | 0.74 | TYR (1.00) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| SCHEMBL7213666 | 0.73 | ESRRB (0.42) | TYRNR1H4MAOBALDH1A1CYP3A4 | |
| SCHEMBL4456426 | 0.72 | TYR (0.96) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| SCHEMBL11420339 | 0.72 | TYR (0.96) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| SCHEMBL28337239 | 0.72 | TYR (0.96) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| Hydrogen Sulfide SCHEMBL28156220 | 0.72 | TYR (0.96) | TYRTRIM24TRIM33ERN1ALDH1A1 | |
| SCHEMBL28150290 | 0.72 | TYR (0.96) | TYRTRIM24TRIM33ERN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134678-A2 | N-(5, 6, 7, 8-TETRAHYDRONAPHTHALEN-1-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS TRPV1 VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | Abbott Laboratories (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008079683-A2 | N- (5, 6, 7, 8-TETRAHYDRONAPHTHALEN-1-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS TRPV1 VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | WO | disclosed |