Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380912 | 0.87 | HCAR2 (0.54) | KDM4CDAOKDM4EHCAR2KDM4A | |
| SCHEMBL3920671 | 0.86 | DAO (0.54) | KDM4CDAOKDM4ETSHRCASP1 | |
| SCHEMBL4438025 | 0.85 | KDM4E (0.41) | KDM4CKDM2BKDM4EHCAR2SMN1; SMN2 | |
| SCHEMBL4433217 | 0.82 | KDM4E (0.41) | KDM4CDAOKDM4EHCAR2SMN1; SMN2 | |
| SCHEMBL3912930 | 0.81 | KDM4E (0.53) | KDM4CDAOKDM4EHCAR2SMN1; SMN2 | |
| SCHEMBL4376037 | 0.81 | KDM5B (0.41) | KDM4CKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4372824 | 0.79 | KDM5A (0.55) | KDM4CDAOKDM4EALDH1A1KDM4A | |
| SCHEMBL4431491 | 0.78 | HCAR2 (0.54) | KDM4CKDM4EHCAR2KDM4AKDM5A | |
| SCHEMBL4428237 | 0.78 | KDM4E (0.50) | KDM4CDAOKDM4EHCAR2TSHR | |
| SCHEMBL11836193 | 0.78 | KDM4E (0.42) | KDM4CDAOKDM4ETSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |