Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.39 |
| ▸ | KDM4A | O75164 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438025 | 0.87 | KDM4E (0.41) | HCAR2MMP9KDM4EKDM5BKDM4A | |
| SCHEMBL4432424 | 0.86 | HNF4A (0.49) | HCAR2KDM4EPARP1KDM5BKDM4A | |
| SCHEMBL4430805 | 0.84 | KDM4E (0.47) | HCAR2MMP1MMP2MMP9MMP12 | |
| SCHEMBL3912930 | 0.84 | KDM4E (0.53) | HCAR2KDM4EPARP1KDM5BKDM4A | |
| SCHEMBL4438623 | 0.83 | HCAR2 (0.54) | HCAR2MMP1MMP2MMP9MMP12 | |
| SCHEMBL4430692 | 0.83 | KDM4E (0.51) | MMP1MMP2MMP12KDM4EKDM5B | |
| SCHEMBL4380912 | 0.83 | HCAR2 (0.54) | HCAR2MMP1MMP2MMP9MMP12 | |
| SCHEMBL4438787 | 0.83 | KDM4E (0.41) | HCAR2KDM4EPARP1KDM5BKDM4A | |
| SCHEMBL4430485 | 0.82 | KDM4E (0.41) | HCAR2KDM4EKDM5BKDM4AKDM6B | |
| SCHEMBL4428237 | 0.81 | KDM4E (0.50) | HCAR2KDM4EPARP1KDM5BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125739-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079371-A1 | MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |