SCHEMBL4380912

SCHEMBL4380912

O=C(O)c1ccc(Cc2cccc(Cl)c2)[nH]c1=O

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.54
DAO P14920 4/20 0.52
PDE5A O76074 3/20 0.50
BRS3 P32247 1/20 0.48
KDM4A O75164 1/20 0.48
KDM4C Q9H3R0 1/20 0.48
KDM5B Q9UGL1 1/20 0.48
PDE3B Q13370 1/20 0.46
PDE3A Q14432 1/20 0.46
DHODH Q02127 1/20 0.43
PIK3CA P42336 1/20 0.42
EGFR P00533 1/20 0.41
CTBP2 P56545 1/20 0.41
MMP1 P03956 1/20 0.41
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP12 P39900 1/20 0.41
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4430818 0.87 KDM4C (0.45) HCAR2DAOPDE5AKDM4AKDM4C
SCHEMBL4432424 0.86 HNF4A (0.49) HCAR2DAOKDM4AKDM4CKDM5B
SCHEMBL4437957 0.84 PDE3B (0.51) HCAR2DAOPDE5APDE3BPDE3A
SCHEMBL3912930 0.84 KDM4E (0.53) HCAR2DAOBRS3KDM4AKDM4C
SCHEMBL4438787 0.83 KDM4E (0.41) HCAR2DAOPDE5AKDM4AKDM4C
SCHEMBL4430692 0.83 KDM4E (0.51) KDM4AKDM4CKDM5BDHODHMMP1
SCHEMBL4431491 0.83 HCAR2 (0.54) HCAR2KDM4AKDM4CKDM5BMMP1
SCHEMBL4438623 0.83 HCAR2 (0.54) HCAR2DAOBRS3PDE3BPDE3A
SCHEMBL3920671 0.82 DAO (0.54) DAOBRS3KDM4AKDM4CKDM5B
SCHEMBL4428237 0.81 KDM4E (0.50) HCAR2DAOBRS3KDM4AKDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019391-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO. INC. (US) 2000-07-19 EP claimed
WO-1999018096-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-04-15 WO claimed
EP-2125739-A1 MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF ENCYSIVE PHARMACEUTICALS, INC. (US) 2009-12-02 EP disclosed
EP-2038272-A2 PYRIDINONYL PDK1 INHIBITORS Sunesis Pharmaceuticals, Inc. (US) 2009-03-25 EP disclosed
WO-2008079371-A1 MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF ENCYSIVE PHARMACEUTICALS, INC. (US) 2008-07-03 WO disclosed
WO-2008005457-A2 PYRIDINONYL PDK1 INHIBITORS SUNESIS PHARMACEUTICALS (US) 2008-01-10 WO disclosed
EP-1019391-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO. INC. (US) 2000-07-19 EP disclosed
WO-1999018096-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-04-15 WO disclosed