Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48744 | 0.65 | PIP4K2A (0.39) | LMNARECQLTDP1 | |
| SCHEMBL7468817 | 0.59 | ALDH1A1 (0.40) | L3MBTL1POLBCYP1A2LMNARAB9A | |
| SCHEMBL18249739 | 0.57 | ALDH1A1 (0.31) | — | |
| SCHEMBL1421249 | 0.57 | BACE1 (0.53) | — | |
| SCHEMBL1421251 | 0.57 | BACE1 (0.53) | — | |
| SCHEMBL29954898 | 0.54 | TRIM24 (0.46) | L3MBTL1CYP1A2RAB9A | |
| SCHEMBL23450058 | 0.54 | ALDH1A1 (0.62) | L3MBTL1POLBRAB9A | |
| SCHEMBL9510452 | 0.54 | KDM4E (0.38) | L3MBTL1RAB9ATDP1 | |
| SCHEMBL30999728 | 0.54 | ALDH1A1 (0.43) | POLB | |
| SCHEMBL11158894 | 0.53 | SRC (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061787-A2 | 5-(2-FURYL)-1,3-THIAZOLE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Vertex Pharmaceuticals Incorporated (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008027584-A2 | 5- (2-FURYL)-1, 3-THIAZOLE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-06 | — | — | WO | disclosed |