Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 7/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | FSHR | P23945 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327613 | 0.90 | LHCGR (0.77) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL2131332 | 0.90 | LHCGR (0.61) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL6216802 | 0.90 | LHCGR (0.61) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL6216192 | 0.90 | ALDH1A1 (0.62) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL6220445 | 0.88 | LHCGR (0.65) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL4426414 | 0.87 | LHCGR (0.57) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL6217536 | 0.86 | LHCGR (0.63) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL6217498 | 0.86 | LHCGR (0.62) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL5025967 | 0.86 | LHCGR (0.62) | LHCGRTSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL4421145 | 0.86 | BRAF (0.62) | LHCGRTSHRFSHRBRAFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618963-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2009-11-17 | — | — | US | disclosed |
| US-7375109-B2 | Glycine-substituted thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-05-20 | — | — | US | disclosed |
| EP-1886999-A2 | Bicyclic heteroaromatic compound | N.V. Organon (NL) | 2008-02-13 | — | — | EP | disclosed |
| EP-1322651-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS | ORGANON NV (NL) | 2008-01-23 | — | — | EP | disclosed |
| US-7317006-B2 | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-01-08 | — | — | US | disclosed |
| US-20070197527-A1 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-08-23 | — | — | US | disclosed |
| US-7229990-B2 | Bicyclic heteroaromatic compounds | N.V. ORGANON (NL) | 2007-06-12 | — | — | US | disclosed |
| EP-1427733-B1 | THIENO[2,3-D]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | ORGANON NV (NL) | 2006-11-15 | — | — | EP | disclosed |
| EP-1427734-B1 | GLYCINE-SUBSTITUTED THIENO[2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | AKZO NOBEL NV (NL) | 2005-11-09 | — | — | EP | disclosed |
| US-6841553-B2 | Bicyclic heteroaromatic compounds useful as LH agonists | AKZO NOBEL N.V. (NL) | 2005-01-11 | — | — | US | disclosed |
| US-20040180907-A1 | Glycine-substituted thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | MERCK SHARP & DOHME B.V. (NL) | 2004-09-16 | — | — | US | disclosed |
| US-20040180873-A1 | Thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | MERCK SHARP & DOHME B.V. (NL) | 2004-09-16 | — | — | US | disclosed |
| US-20030225113-A1 | Bicyclic heteroaromatic compounds | MERCK SHARP & DOHME B.V. (NL) | 2003-12-04 | — | — | US | disclosed |
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | MERCK SHARP & DOHME B.V. (NL) | 2003-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212081-A1 | Bicyclic heteroaromatic compounds useful as LH agonists | LHCGR, GNRHR, FSHR | LHCGR 1/4885TSHR 176/4885KDM4E 2123/4885 |
| US-20030225113-A1 | Bicyclic heteroaromatic compounds | NR5A1, CYP19A1, FSHR | LHCGR 13/4885TSHR 1000/4885KDM4E 1309/4885 |
| US-20040180907-A1 | Glycine-substituted thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | FSHR, GNRHR, LHCGR | LHCGR 3/4885TSHR 45/4885KDM4E 1976/4885 |
| US-20040180873-A1 | Thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | FSHR, GNRHR, LHCGR | LHCGR 3/4885TSHR 14/4885KDM4E 2994/4885 |
| US-20070197527-A1 | Bicyclic heteroaromatic compounds | NR5A1, CYP19A1, FSHR | LHCGR 10/4885TSHR 517/4885KDM4E 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.