Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 8/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | FSHR | P23945 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421145 | 0.91 | BRAF (0.62) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL6216455 | 0.90 | LHCGR (0.59) | LHCGRTSHRFSHRMAPTALDH1A1 | |
| SCHEMBL2133864 | 0.89 | LHCGR (0.60) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL4419261 | 0.88 | LHCGR (0.77) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL6927090 | 0.86 | LHCGR (0.64) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL4431522 | 0.86 | LHCGR (0.62) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL14285233 | 0.86 | LHCGR (0.56) | LHCGRTSHRFSHRMAPTALDH1A1 | |
| SCHEMBL4421168 | 0.86 | LHCGR (0.84) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL4899220 | 0.83 | BRAF (0.61) | LHCGRTSHRBRAFPDE4APDE4B | |
| SCHEMBL4427626 | 0.83 | BRAF (0.54) | LHCGRBRAFPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375109-B2 | Glycine-substituted thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-05-20 | — | — | US | disclosed |
| US-7317006-B2 | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-01-08 | — | — | US | disclosed |
| EP-1427733-B1 | THIENO[2,3-D]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | ORGANON NV (NL) | 2006-11-15 | — | — | EP | disclosed |
| EP-1427734-B1 | GLYCINE-SUBSTITUTED THIENO[2,3-d]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | AKZO NOBEL NV (NL) | 2005-11-09 | — | — | EP | disclosed |
| US-20040180907-A1 | Glycine-substituted thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | MERCK SHARP & DOHME B.V. (NL) | 2004-09-16 | — | — | US | disclosed |
| US-20040180873-A1 | Thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | MERCK SHARP & DOHME B.V. (NL) | 2004-09-16 | — | — | US | disclosed |
| EP-1427733-A1 | THIENO 2,3-D]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | Akzo Nobel N.V. (NL) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003020726-A1 | THIENO[2,3-D]PYRIMIDINES WITH COMBINED LH AND FSH AGONISTIC ACTIVITY | AKZO NOBEL N.V. (NL) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180907-A1 | Glycine-substituted thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | FSHR, GNRHR, LHCGR | LHCGR 3/4885TSHR 45/4885BRAF 4677/4885 |
| US-20040180873-A1 | Thieno{2,3-d}pyrimidines with combined lh and fsh agonistic activity | FSHR, GNRHR, LHCGR | LHCGR 3/4885TSHR 14/4885BRAF 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.