Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.34 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434206 | 0.92 | HTT (0.38) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4443357 | 0.89 | PIK3CD (0.40) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4433726 | 0.88 | HTT (0.37) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4443103 | 0.87 | LMNA (0.40) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4435698 | 0.86 | HTT (0.37) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4434824 | 0.85 | LMNA (0.42) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4429984 | 0.85 | PIK3CD (0.37) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL16799113 | 0.84 | LMNA (0.39) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4433351 | 0.83 | MAP4K4 (0.41) | HTTLMNASMN1; SMN2MAPK1PAK4 | |
| SCHEMBL4433753 | 0.81 | MAPK1 (0.37) | HTTLMNASMN1; SMN2MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |