Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 4/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434824 | 0.90 | LMNA (0.42) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL16799113 | 0.87 | LMNA (0.39) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4433351 | 0.86 | MAP4K4 (0.41) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4435698 | 0.83 | HTT (0.37) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4434206 | 0.82 | HTT (0.38) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4443357 | 0.81 | PIK3CD (0.40) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4431745 | 0.81 | HTT (0.38) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4185136 | 0.80 | PIK3CD (0.49) | MAPK1HTTLMNAPIK3CDAURKA | |
| SCHEMBL4433726 | 0.80 | HTT (0.37) | MAPK1HTTLMNASMN1; SMN2PIK3CD | |
| SCHEMBL4179093 | 0.79 | PIK3CG (0.44) | PIK3CDAURKARPS6KB1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |