Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HHAT | Q5VTY9 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LHCGR | P22888 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430893 | 0.86 | HHAT (0.38) | HHATKDM4EALDH1A1LHCGRPOLB | |
| SCHEMBL2992670 | 0.82 | BRD4 (0.43) | HHATKDM4EALDH1A1NPSR1BRD4 | |
| SCHEMBL2992674 | 0.82 | BRD4 (0.43) | HHATKDM4EALDH1A1NPSR1BRD4 | |
| SCHEMBL2992673 | 0.82 | BRD4 (0.43) | HHATKDM4EALDH1A1NPSR1BRD4 | |
| SCHEMBL3302731 | 0.74 | HHAT (0.44) | HHATLHCGRPOLBMAPK1NPSR1 | |
| SCHEMBL3302736 | 0.74 | HHAT (0.44) | HHATLHCGRPOLBMAPK1NPSR1 | |
| SCHEMBL4749248 | 0.74 | HHAT (0.44) | HHATLHCGRPOLBMAPK1NPSR1 | |
| SCHEMBL4440748 | 0.72 | NOS3 (0.35) | KDM4EALDH1A1POLBMAPK1 | |
| SCHEMBL4751245 | 0.71 | DRD2 (0.40) | HHATLHCGRPOLBMAPK1NPSR1 | |
| SCHEMBL3304815 | 0.71 | DRD2 (0.40) | HHATLHCGRPOLBMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132193-B1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2132193-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | Boehringer Ingelheim International GmbH (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116881-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-02 | — | — | WO | disclosed |