Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441650 | 0.91 | PDE10A (0.41) | PDE10AP2RX7HTTTRPV3 | |
| SCHEMBL4430282 | 0.90 | PDE10A (0.46) | PDE10AP2RX7LMNAMAPK1TRPV3 | |
| SCHEMBL4435328 | 0.87 | TRPV1 (0.39) | PDE10AP2RX7ENPP1TRPV1PTGS1 | |
| SCHEMBL4435714 | 0.86 | PDE10A (0.41) | PDE10AP2RX7TRPV3PDE4APDE4B | |
| SCHEMBL4441805 | 0.85 | P2RX7 (0.42) | PDE10AP2RX7PTGS1PTGS2 | |
| SCHEMBL4434674 | 0.84 | PDE10A (0.42) | PDE10AP2RX7MAPK1TRPV3 | |
| SCHEMBL4440442 | 0.82 | KCNN4 (0.38) | PDE10AP2RX7TRPV3PDE2A | |
| SCHEMBL4428091 | 0.81 | P2RX7 (0.38) | P2RX7MAPK1TRPV3 | |
| SCHEMBL4433321 | 0.81 | PDE10A (0.42) | PDE10AP2RX7MAPK1TRPV3 | |
| SCHEMBL4434555 | 0.81 | PDE4A (0.46) | PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |