Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 13/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432368 | 0.87 | PDE10A (0.41) | TRPV1P2RX7ENPP1PDE10APTGS2 | |
| SCHEMBL4441650 | 0.84 | PDE10A (0.41) | P2RX7PDE10A | |
| SCHEMBL4430282 | 0.81 | PDE10A (0.46) | P2RX7PDE10A | |
| SCHEMBL4433610 | 0.80 | CNR1 (0.37) | P2RX7PDE10A | |
| SCHEMBL4428091 | 0.80 | P2RX7 (0.38) | P2RX7 | |
| SCHEMBL4435714 | 0.80 | PDE10A (0.41) | P2RX7PDE10A | |
| SCHEMBL4441805 | 0.79 | P2RX7 (0.42) | P2RX7PDE10APTGS2PTGS1 | |
| SCHEMBL4440442 | 0.79 | KCNN4 (0.38) | P2RX7PDE10A | |
| SCHEMBL4434674 | 0.78 | PDE10A (0.42) | P2RX7PDE10A | |
| SCHEMBL4433321 | 0.78 | PDE10A (0.42) | P2RX7PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |