Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432368 | 0.90 | PDE10A (0.41) | PDE10AP2RX7TRPV3LMNAMAPK1 | |
| SCHEMBL4435714 | 0.90 | PDE10A (0.41) | PDE10AP2RX7TRPV3AKR1C3AKR1C2 | |
| SCHEMBL4441650 | 0.90 | PDE10A (0.41) | PDE10AP2RX7ALDH1A1TRPV3AKR1C3 | |
| SCHEMBL4441805 | 0.89 | P2RX7 (0.42) | PDE10AP2RX7CYP2C19KMT2ACYP1A2 | |
| SCHEMBL4434555 | 0.85 | PDE4A (0.46) | — | |
| SCHEMBL4434674 | 0.83 | PDE10A (0.42) | PDE10AP2RX7TRPV3NTRK1CSF1R | |
| SCHEMBL4434628 | 0.83 | AKR1C3 (0.51) | CYP2C19ACHEAKR1C3AKR1C2KMT2A | |
| SCHEMBL4433733 | 0.82 | P2RX7 (0.42) | PDE10AP2RX7ALDH1A1TRPV3LMNA | |
| SCHEMBL4440442 | 0.82 | KCNN4 (0.38) | PDE10AP2RX7TRPV3 | |
| SCHEMBL4435328 | 0.81 | TRPV1 (0.39) | PDE10AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |