Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3648250 | 0.90 | MAPT (0.61) | MAPTFFAR1TAAR1RORCBCHE | |
| SCHEMBL13522307 | 0.88 | MAPT (0.64) | MAPTMCHR1FFAR1TAAR1ALDH1A1 | |
| SCHEMBL26267825 | 0.87 | KIF11 (0.56) | MCHR1FFAR1TAAR1HDAC1HDAC8 | |
| SCHEMBL26267845 | 0.84 | TAAR1 (0.53) | MCHR1FFAR1TAAR1HDAC1HDAC8 | |
| SCHEMBL27610543 | 0.83 | ALDH1A1 (0.53) | MAPTMCHR1FFAR1TAAR1HDAC1 | |
| SCHEMBL26268161 | 0.83 | MCHR1 (0.46) | MAPTMCHR1FFAR1TAAR1HDAC1 | |
| SCHEMBL4433139 | 0.83 | MAPT (0.57) | MAPTMCHR1FFAR1ALDH1A1GAA | |
| SCHEMBL24119313 | 0.83 | TAAR1 (0.53) | TAAR1HDAC1HDAC8BCHEACHE | |
| Hydrochloric Acid SCHEMBL4430212 | 0.83 | CNR1 (0.57) | MAPTMCHR1FFAR1TAAR1HDAC1 | |
| Hydrochloric Acid SCHEMBL4433362 | 0.82 | L3MBTL1 (0.55) | MAPTMCHR1FFAR1TAAR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |