SCHEMBL4432906

SCHEMBL4432906

COc1cccc(-c2ccc3cccc(OC)c3n2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 1/20 0.54
MCHR1 Q99705 1/20 0.51
GAK O14976 2/20 0.46
PARP1 P09874 1/20 0.46
PDGFRB P09619 2/20 0.46
PDGFRA P16234 1/20 0.46
ALDH1A1 P00352 2/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
MAPT P10636 1/20 0.46
THRB P10828 1/20 0.46
BLM P54132 1/20 0.46
CASP6 P55212 1/20 0.46
KMT2A Q03164 1/20 0.46
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 1/20 0.46
NQO2 P16083 1/20 0.45
KIT P10721 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8889339 0.84 MCHR1 (0.57) MCHR1PARP1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL19603062 0.82 MCHR1 (0.67) MCHR1ALDH1A1RAB9APOLBMAPT
SCHEMBL28108403 0.80 NPSR1 (0.48) MCHR1ALDH1A1SMN1; SMN2KDM4EMIF
SCHEMBL13870935 0.80 PDGFRB (0.61) MAP4K4PDGFRBPDGFRAALDH1A1RAB9A
SCHEMBL4701200 0.79 NPC1 (0.69) MCHR1PDGFRBPDGFRARAB9APOLB
SCHEMBL3630297 0.78 DYRK1A (0.58) MAP4K4ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL29470234 0.78 DYRK1A (0.58) MAP4K4ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL6851588 0.78 RAB9A (0.69) MAP4K4ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL29746123 0.78 RAB9A (0.69) MAP4K4ALDH1A1RAB9ASMN1; SMN2MAPT
SCHEMBL20660519 0.77 MCHR1 (0.54) MAP4K4MCHR1PARP1ALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2131826-A2 17BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES Universität des Saarlandes (DE) 2009-12-16 EP disclosed
WO-2008116920-A2 17BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES Universität des Saarlandes (DE) 2008-10-02 WO disclosed