Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PRKCH | P24723 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889339 | 0.84 | MCHR1 (0.57) | NPC1MCHR1RAB9APDE10AKDM4E | |
| SCHEMBL19603062 | 0.82 | MCHR1 (0.67) | NPC1MCHR1RAB9APDE10APOLB | |
| SCHEMBL4432906 | 0.79 | MAP4K4 (0.54) | NPC1MCHR1RAB9ACYP19A1POLB | |
| SCHEMBL22831704 | 0.78 | MCHR1 (0.63) | NPC1MCHR1PDE10AMIF | |
| SCHEMBL4702517 | 0.77 | NPC1 (0.80) | NPC1CYP2A6CYP11B2RAB9ACYP19A1 | |
| SCHEMBL1030196 | 0.76 | HSP90AA1 (0.54) | NPC1CYP2A6CYP11B2CYP19A1CYP11B1 | |
| SCHEMBL22901625 | 0.76 | PDE10A (0.56) | NPC1MCHR1RAB9ACYP19A1PDE10A | |
| SCHEMBL29496195 | 0.76 | CYP2A6 (0.51) | NPC1CYP2A6CYP11B2RAB9ACYP19A1 | |
| SCHEMBL28721995 | 0.76 | CYP2A6 (0.51) | NPC1CYP2A6CYP11B2RAB9ACYP19A1 | |
| Bromide SCHEMBL7398620 | 0.76 | NPC1 (0.78) | NPC1CYP2A6CYP11B2RAB9ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952832-B1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2008-08-27 | — | — | EP | disclosed |
| EP-0952832-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 1999-11-03 | — | — | EP | disclosed |
| US-5804588-A | TREATING DISEASES THAT ARE MODULATED BY INHIBITION OF PHOSPHODIESTERASE IV OR TUMOUR NECROSIS FACTOR | CHIROSCIENCE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |
| WO-1997044036-A1 | QUINOLINE CARBOXAMIDES AS TNF INHIBITORS AND AS PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |