Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.62 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.62 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4433367 | 0.98 | HRH1 (0.64) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL23960430 | 0.87 | CYP19A1 (0.54) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL4432789 | 0.86 | SLC6A2 (0.48) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL605443 | 0.85 | HTR2A (0.64) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| Hydrochloric Acid SCHEMBL4430219 | 0.84 | SLC6A2 (0.47) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL4433142 | 0.82 | SLC6A2 (0.55) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL158098 | 0.82 | HRH1 (1.00) | HRH1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7294209 | 0.81 | HRH3 (0.48) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| SCHEMBL4432893 | 0.81 | SLC6A2 (0.51) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 | |
| Hydrochloric Acid SCHEMBL4441383 | 0.80 | SLC6A2 (0.54) | HRH1SLC6A2SLC6A4SLC6A3KCNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748982-A1 | (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005108362-A1 | (4, 5, 6, 7-TETRAHYDRO-1-H-INDOL-7-YL) ACETIC ACID DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2005-11-17 | — | — | WO | disclosed |