Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161949 | 0.86 | HRH1 (0.67) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| SCHEMBL13930329 | 0.85 | HRH1 (0.62) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Hydrochloric Acid SCHEMBL4433367 | 0.84 | HRH1 (0.64) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| SCHEMBL23960430 | 0.84 | CYP19A1 (0.54) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| SCHEMBL4433142 | 0.82 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| Hydrochloric Acid SCHEMBL4430219 | 0.81 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| Hydrochloric Acid SCHEMBL4441383 | 0.81 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| SCHEMBL27790948 | 0.79 | BCHE (0.40) | CYP19A1UTS2RKIF11 | |
| SCHEMBL4434677 | 0.77 | CASR (0.45) | SLC6A2SLC6A4SLC6A3KCNK2KCNH2 | |
| SCHEMBL12569047 | 0.76 | BCHE (0.42) | TAAR1UTS2RKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |