Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4424429 | 0.89 | MEN1 (0.70) | MEN1KMT2AGAALMNAHPGD | |
| Bicarbonate SCHEMBL4423971 | 0.88 | KMT2A (0.72) | MEN1KMT2AGAALMNAHPGD | |
| Bicarbonate SCHEMBL4421862 | 0.88 | KMT2A (0.72) | MEN1KMT2AGAALMNAHPGD | |
| Bicarbonate SCHEMBL4428121 | 0.86 | GAA (0.66) | MEN1KMT2AGAALMNAHPGD | |
| Bicarbonate SCHEMBL7620040 | 0.86 | SIGMAR1 (0.55) | MEN1KMT2ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL4435470 | 0.86 | MEN1 (0.51) | MEN1KMT2AGAALMNAHPGD | |
| Bicarbonate SCHEMBL8553237 | 0.85 | LMNA (0.49) | MEN1KMT2AGAALMNAHPGD | |
| Bicarbonate SCHEMBL4425148 | 0.83 | MEN1 (0.56) | MEN1KMT2AGAAHPGDSMN1; SMN2 | |
| Bicarbonate SCHEMBL4421056 | 0.81 | MEN1 (0.56) | MEN1KMT2AGAALMNAHPGD | |
| SCHEMBL9093507 | 0.80 | MEN1 (0.58) | MEN1KMT2AGAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741700-B1 | 1-H-3-ARYLPYRROLIDINE-2,4-DIONE DERIVATIVES AS PEST-CONTROL AGENTS | BAYER CROPSCIENCE AG (DE) | 2009-10-07 | — | — | EP | disclosed |