Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432811 | 0.88 | PIK3CD (0.43) | PIK3CDDPP4CCR1CCR8L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4437577 | 0.88 | PIK3CD (0.43) | PIK3CDDPP4CCR1CCR8L3MBTL1 | |
| SCHEMBL4433320 | 0.83 | PIK3CD (0.43) | PIK3CDDPP4TAAR1 | |
| SCHEMBL16712480 | 0.82 | PIK3CD (0.42) | PIK3CDDPP4CCR1CCR8L3MBTL1 | |
| SCHEMBL4442988 | 0.80 | PIK3CD (0.63) | PIK3CDL3MBTL1GAA | |
| SCHEMBL16585320 | 0.79 | PIK3CD (0.47) | PIK3CDDPP4CCR1CCR8L3MBTL1 | |
| SCHEMBL4175840 | 0.77 | PIK3CD (0.45) | PIK3CDCCR1CCR8L3MBTL1P2RX7 | |
| SCHEMBL4178020 | 0.77 | CCR1 (0.39) | PIK3CDCCR1CCR8L3MBTL1ALDH1A1 | |
| SCHEMBL10251837 | 0.76 | PIK3CD (0.43) | PIK3CDCCR1CCR8L3MBTL1ADORA2A | |
| SCHEMBL4178087 | 0.75 | DPP4 (0.51) | PIK3CDDPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |