Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 13/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | EEF2K | O00418 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436009 | 0.85 | MEN1 (0.43) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL22917200 | 0.84 | GAA (0.50) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL4433967 | 0.84 | ACP3 (0.41) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL28226380 | 0.83 | HDAC4 (0.46) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL4432350 | 0.82 | AKR1C3 (0.45) | ACP3AKR1C3AKR1C2CES2CES1 | |
| SCHEMBL2304585 | 0.82 | ACP3 (0.56) | EEF2KACP3CES2CES1CNR2 | |
| SCHEMBL2304513 | 0.81 | CNR2 (0.47) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL4428068 | 0.81 | AKR1C3 (0.41) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL22917054 | 0.80 | CES2 (0.48) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL27792689 | 0.78 | HDAC4 (0.42) | HDAC4HDAC3HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |