Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433475 | 1.00 | TAAR1 (0.46) | TAAR1VNN1ALDH1A1LMNAMAPK1 | |
| SCHEMBL12085750 | 0.89 | VNN1 (0.41) | TAAR1VNN1ALDH1A1MAPT | |
| SCHEMBL21930188 | 0.89 | VNN1 (0.41) | TAAR1VNN1ALDH1A1MAPT | |
| SCHEMBL21929958 | 0.89 | VNN1 (0.41) | TAAR1VNN1ALDH1A1MAPT | |
| SCHEMBL8374148 | 0.86 | TAAR1 (0.43) | TAAR1VNN1ALDH1A1LMNAMAPK1 | |
| SCHEMBL30744688 | 0.85 | ALDH1A1 (0.47) | TAAR1VNN1ALDH1A1POLBKDM4E | |
| SCHEMBL4115177 | 0.85 | ALDH1A1 (0.43) | TAAR1VNN1ALDH1A1POLBKDM4E | |
| SCHEMBL31691616 | 0.83 | TAAR1 (0.41) | TAAR1VNN1ALDH1A1LMNAMAPK1 | |
| SCHEMBL27935627 | 0.83 | TAAR1 (0.41) | TAAR1VNN1ALDH1A1LMNAMAPK1 | |
| SCHEMBL7291396 | 0.83 | TAAR1 (0.40) | TAAR1VNN1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024359-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DECEASE AND/OR SCHIZOPHRENIA | AstraZeneca AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007126362-A1 | COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DISEASE AND/OR SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | WO | disclosed |