Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434674 | 0.88 | PDE10A (0.42) | P2RX7PDE10ATRPV3CTSA | |
| SCHEMBL4430282 | 0.82 | PDE10A (0.46) | P2RX7PDE10AMEN1KMT2AALDH1A1 | |
| SCHEMBL4441805 | 0.82 | P2RX7 (0.42) | P2RX7IGF1RPDE10ACYP3A4MEN1 | |
| SCHEMBL4433321 | 0.81 | PDE10A (0.42) | P2RX7PDE10ATRPV3 | |
| SCHEMBL4441650 | 0.81 | PDE10A (0.41) | P2RX7PDE10AALDH1A1TRPV3 | |
| SCHEMBL4432368 | 0.81 | PDE10A (0.41) | P2RX7PDE10ATRPV3LMNA | |
| SCHEMBL4435714 | 0.78 | PDE10A (0.41) | P2RX7PDE10ATRPV3 | |
| SCHEMBL4434384 | 0.78 | P2RX7 (0.48) | P2RX7CYP3A4 | |
| SCHEMBL4433610 | 0.76 | CNR1 (0.37) | P2RX7PDE10AMEN1KMT2A | |
| SCHEMBL4429753 | 0.75 | P2RX7 (0.43) | P2RX7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |